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There are many common drug interactions with grapefruit juice. Medicines that can interact include certain cholesterol medicines, antihistamines, migraine treatments or even cancer therapies. If you eat grapefruit or drink the juice, review your medications with a healthcare provider to rule out this common drug-food interaction. PROZAC and Olanzapine in Combination Use a starting dose of oral olanzapine 2.5 to 5 mg with fluoxetine 20 mg for patients with a predisposition to hypotensive reactions, patients with hepatic impairment, or patients who exhibit a combination of factors that may slow the metabolism of olanzapine or fluoxetine in combination (female gender prozac and grapefruit For this condition, Prozac is used together with olanzapine (Zyprexa). Dosage for depression. For depression in children, Prozac s usual starting dosage is 10 mg per day to 20 mg per day. The list of medicines known to interact with grapefruit has grown longer. We’ve known for twenty years it’s not safe to mix grapefruit and some prescription drugs. Eighty-five Fluoxetine is an antidepressant medication commonly sold under the brand name Prozac that s useful in treating mood disorders, bulimia nervosa, and obsessive-compulsive disorder, among others.